49ers vs. Colts live score, updates, highlights from NFL 'Monday Night Football' game originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here.
JUMP TO:
Week 16 comes to a close on Monday night as the Indianapolis Colts host the San Francisco 49ers for "Monday Night Football."
With the action of the week so far, the 49ers have officially clinched a playoff spot. San Francisco heads into this matchup as the No. 6 seed, but still has a mathematical chance at the No. 1 seed for the NFC. The 49ers need to win out, and need a lot of outside help for it to happen, but it is plausible.
The Colts are currently on the outside looking in for the AFC playoff picture. Indianapolis's best chance of making the playoffs comes as a wild-card team. The Colts aren't eliminated from playoff contention with a loss, but it makes the playoffs tougher to reach. Indianapolis will turn once again to veteran quarterback Philip Rivers, who is looking to notch his first win since coming out of retirement.
The Sporting News is tracking live scores, updates and highlights from Colts vs. 49ers on Monday night.
STREAM: Watch 49ers vs. Colts live with Fubo (free trial)
49ers vs. Colts score
NFL HQ:Live NFL scores | Full NFL schedule | Updated NFL standings
49ers vs. Colts live updates, highlights from 'Monday Night Football'
6:10 p.m.: 44-year-old Philip Rivers makes his second start in 2025 tonight against the 2022 Mr. Irrelevant, Brock Purdy.
Different eras. Same spotlight.
— OurSF49ers (@OurSf49ers) December 22, 2025
Brock Purdy and Philip Rivers face off on MNF 🔥 pic.twitter.com/czJ20klhoX
You can follow Rivers' stats from "Monday Night Football" here.
5:43 p.m.: Tonight, DeForest Buckner plays the team that drafted him with the seventh overall pick in 2016.
what Buck said. pic.twitter.com/ZFnEh4PvKq
— Indianapolis Colts (@Colts) December 22, 2025
MORE NFL WEEK 16:
- How Travis Kelce's retirement decision is easy with no Patrick Mahomes
- Panthers take control of NFC South with massive win over Buccaneers
- Myles Garrett inches closer to NFL sack record with obscure half sack
- Gardner Minshew suffers potential ACL tear in first Chiefs game without Patrick Mahomes
- Quinshon Judkins out for season after gruesome leg injury vs. Bills
Where to watch 49ers vs. Colts
49ers vs. Colts start time
- Date: Monday, December 22
- Start time: 8:15 p.m. ET
Week 16's "Monday Night Football" game between the 49ers and the Colts will be held at Lucas Oil Stadium in Indianapolis, Indiana. Kickoff is set for 8:15 p.m. ET.
Joe Buck will be the play-by-play analyst for the game, with Troy Aikman serving as the color commentator. Erin Andrews and Tom Rinaldi will be the sideline reporters for the game.
What channel is 49ers vs. Colts on today?
The Week 16 matchup between the 49ers and the Colts will be broadcast on ESPN, and simulcast on ABC. There will also be an alternative broadcast on ESPN2, with Field Yates, Dan Orlovsky and Luke Kuechly.
A live stream will be available on the ESPN App as well as Fubo, which carries ESPN and ABC in its channel lineup and is currently offering a free trial.
MORE: Updated AFC, NFC playoff pictures in Week 16
49ers remaining schedule
With a playoff berth clinched, here is how San Francisco closes out the regular season.
| Date | Game | Time (ET) |
| Sun., Dec. 28 | vs. Bears (SNF) | 8:20 p.m. |
| TBD | vs. Seahawks | TBD |
MORE: Updated 2026 NFL Draft order in Week 16
Colts remaining schedule
Here is how Indianapolis will end the regular season.
| Date | Game | Time (ET) |
| Sun., Dec. 28 | vs. Jaguars | 1 p.m. |
| TBD | at Texans | TBD |